Background and Objectives: Acute myocardial infarction (MI) is usually accompanied by leukocytosis and increased neutrophils. However , still it has not been definitely recognized that whether this process is caused by myocardial defects or not. Few studies are availale which have reported about the relationship between neutrophil and short - term risks of myocardial complications such as CONGESTIVE HEART FAILURE (CHF) after MI. In this case neutrophil count can be used as a predictor for CHF in patients with acute myocardial infarction.Materials and Methods: A sectional study was carried out on a population of patients with MI who had been hospitalized in CCU units. Blood samples were withdrawn from all of the patients to count neutrophils and also all interfering agents that could cause an increase in WBC counts were eliminated.Results: Total 50 patients , 84% men and 16% women , were studied. Among these 50 patients , 25 patients were affected by CHF (Ejection Fraction<40%). 32 patients (66%) showed relative neutrophilia (Neutrophil count>66%) while 36% showed no neutrophilia. Two groups were compared by T-test with respect to the average percent of neutrophils and the difference significant statistically ( p=0.001). Totally among 54% of patients who had been affected by CHF,92% showed relative neutrophilia (N> 65 %) at the beginning. Conclusion: This study clearly indicates that the presence of relative neutrophilia in patients with acute MI during the early 12-houre period is completely related to the incidence of CHF at first 4 days.

BACKGROUND AND OBJECTIVE: Coenzyme Q10 (CoQ10) is a provitamin existing in mitocondrial and cellular membranes scavenging free radicals as an antioxidant. This coenzyme also has important role in providing energy in cardiomyocites. Levels of CoQ10 decrease in HEART FAILURE. The treatment of severe CONGESTIVE HEART FAILURE is one of the problems in cardiac patients. The aim of this study was to determine the effect of oral administration of CoQ10 in chronic HEART failur.METHODS: This quasi-experimental study was carried out on 47 patients with CONGESTIVE HEART FAILURE (CLASS III-IV NYHA). In all patients MM, 2D, and Doppler echocardiography were performed and after that they received oral CoQ10 (100 mg) (red-CoQ10) as daily single dose during next three months. After treatment, echocardiography was performed again and the data including left ventricle size, end systolic diameter, end diastolic diameter and severity of MR before and after treatment were compared and analyzed.FINDINGS: The mean±SD was 60.5±12.8 years. Thirty patients (63.8%) were male and 17 patients (36.2%) were female. More than 10 mm decreases were observed in: left ventricle size (in 8.5%), end systolic diameter (in 12.8%), end diastolic diameter (in 19.1%) and increase in ejection fraction in 70.2% of patients that indicated significant differences as compared to before treatment (p=0.000). In dilated cardiomyopathy, more than 10 mm decreases were observed in: left ventricle size, end systolic diameter, and end diastolic diameter in 7.4%, 14.8% and 11.1% of patients, respectively. But in coronary artery disease, more than 10 mm decreases were observed in: left ventricle size, end systolic diameter, and end diastolic diameter in 9.1%, 18.2%, and 45.4% of patients, respectively. Increases in ejection fraction were 74.1% and 63.6% in dilated cardiomyopathy and coronary artery disease, respectively.CONCLUSION: Based on obtained results, supplementing patients' cardiac medicines with CoQ10 made significant improvements in ejection fraction. Additionally, the results of this study show that CoQ10 is effective in coronary artery disease.

Background: Acute myocardial infarction (MI) with inflammatory response is a result of tissue necrosis due to leukocytosis and increased number of peripheral blood neutrophils. Objective: To investigate the relationship between neutrophils and CONGESTIVE HEART FAILURE (CHF). Methods: This cohort study was performed on 100 patients affected by acute MI who had two points out of three standard criteria (physical examination, enzyme and EKG findings) during the last 6 months of 2002 in Yahyanezhad hospital, Babol, Iran. CHF was detected through physical examinations, medical history, chest X-ray, and echocardiography using a CFG 750 VinG Med Instrument at the fourth day of admission. Ejection fraction ≤ 40% was considered as HEART FAILURE. The data included parameters such as ejection fraction, age, sex, location of infarction, time of admission, use of trombolytics accompanied with laboratory reports on leukocyte count, neutrophil and lymphocyte percentage at the first day of admission which were further analyzed using SPSS, Fisher's exact examination, Univariate, and Loglinear statistical tools. Findings: Out of 54 cases with neutrophilia greater than 65% (p=0.003), 25 patients were found to have developed HEART FAILURE at 4th day. There was a significant correlation between both neutrophilia and HEART FAILURE with sex (p<0.05). No significant correlation was found (p>0.05) when the age of patients taken into account. Conclusion: Our data show that the neutrophilia of admission time correlates significantly with HEART FAILURE as an early onset of acute MI.  This could be useful both in detection of high-risk people and also diagnostic and therapeutic measures.  

Hyperthyroidism has been associated with cardiomyopathy and HEART FAILURE (HF). This study aims to evaluate clinical, laboratory and echocardiographic para-meters, at admission and 12 months fol-lowing euthyroidism restoration, in patients with hyperthyroidism-associated HF. Mechanisms un-derlying hyperthyroidism-associated HF and the outcomes of echocardiographic parameters along the study period are both discussed.Materials & Methods: Patients with newly di-agnosed overt hyperthyroidism and HF (Group 1), age and sex-matched euthyroid HF subjects (Group 2), and a control group was enrolled. Results: In the 38-month study period, 56 pa-tients were admitted for hyperthyroidism-associated HF, of whom 71% had a pre-existing, mainly hypertensive, cardiomyopathy vs 68% of Group 2 subjects. Mean HEART rate was signifi-cantly higher in Group 1 than Group 2 (127±38 vs 110±17bpm; P<0.02); 30 Group 1 (54%) and 16 (29%) Group 2 patients presented with atrial fi-brillation. At admission, left ventricular ejection fraction (LVEF), end diastolic (LVEDD) and end systolic (LVESD) diameters were lower, whilst LV mass (LVM), interventricular septum thick-ness (IVST) and LV posterior wall thickness (LVPWT) were increased in both Groups com-pared to controls. At the end of the study, de-spite achievement of euthyroidism in all hyper-thyroid patients, mean LVEF was not significant-ly different in Group 2 but was significantly lower in Group 1 patients compared to controls; LVM, IVST and LVPWT did not change in both study groups.Conclusion: In our series, newly diagnosed hyperthyroidism-associated HF had 2.4% preva-lence. At the end of the study, LVEF significant-ly improved in euthyroid, but not in hyperthy-roidism-associated HF patients compared to con-trols.